As far as my data, FBackup does all of my requirements. I want a copy of my photos (lots!!), 2 iTune libraries, and the usual My Documents and email. FBackup neatly copies the folder and file structure to my USB drive in folders "C" "D" and "E". I actually backup to 2 USB drives and one job is a straight copy, and the other is a mirror that will also delete files from the target (no longer in the source). Schedule it all, and it's PERFECT!!!
I do however have 2 suggestions. One is that I already had all of my files copied to the destination drive, but FBackup took about 4-5 hours to complete and create it's index. I am guessing you should be able to inventory the source and destination to build a faster 1st index?
2nd, I like the way you can choose/add folders OR files. In the mirror/copy mode, it would be nice to be able to check off on the same dialog screen that you add files or folders if you want to delete target files no longer in the source. IF that is not possible, a work around would be to be able to schedule a backup to start after a current one ends instead of guessing how much time to allocate for the schedules. Actually, make that my 3rd suggestion, I like that idea

After the 1st LONG run, if I add about 40 photos, and of course my email files change, the run completes in about 3-4 minutes! Thanks again for a great program!!!